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KMID : 0376219850220030503
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Chonnam Medical Journal
1985 Volume.22 No. 3 p.503 ~ p.515
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Comparison of antibiotic resistances of Escherichia coli strains isolated from antibiotic-treated and -unterated pediatric patients.
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金炯天/Kim, Hyung Chun
柳必悅/吳宗錫/安泰해/Ryu, Phil Yul/Oh, Jong Suk/Ahn, Tai Hew
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Abstract
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One hundred and two strains of E. coli were isolated from patients and newborn infants at Dept. of Pediatrics, Chonnam University Medical School Hospital during early spring, 1985 and submitted to the present test to compare the antibiotic susceptibility patterns between the antibiotic-treated and -untreated groups.
The tested antibiotics were those which were considered as being commonly used without prescription in our country: ampicillin(AP), carbenicillin(CB), cefotiam (CT), moxalactam(MX), amikacin(AK), gentamicin(GM), kanamycin(KM), streptomycin(SM), tobramycin(TM), chloramphenicol(CM), and tetracycline (TC).
Minimum inhibitory concentration(MIC) of each antibiotic was measured against each strain and the degree, distribution and frequency of the resistance were compared between the two groups.
In general, no strain turned out resistant to the third generation cephalosporins, CT and MX, and aminoglycoside, AK, while almost all strains were resistant to AP and TC; intermediate resistance was in the order of SM>CB>CM>KM, and more than 90% were susceptible to GM and KM. Comparison between the two groups, however, revealed some interesting results as follows.
In antibiotic-untreated group, the MIC of TC was unexpectedly high and the rest was in the order of SM>AP>CB>KM>CM, while, in antibiotic-treated group, the conspicuousness of TC resistance disappeared and the general MICs of the other antibiotics became 2~10 times higher, MIC distribution order changing to SM>CM>AP>CB>KM>TC.
Comparison of individual antibiotic MIC between the two groups revealed that among antibiotics of relatively high MIC CM MIC in the antibiotic-treated group (81.8%) was 4 times higher than that(20%) in the antibiotic-untreated one, and KM also showed a significant difference between the two groups (63.6%: 22.5%).
In the multiple resistance test, the antibiotic-treated group revealed that 4 strains were resistant to 8 kinds of tested drugs (18.2%), while in the antibiotic-untreated group no strain turned out resistant to 8 kinds and only 2.5% of strains showing resistant to 7 drugs.
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